Abstract Background Melanoma is a malignant tumor with high misdiagnosis rate and poor prognosis.The bio-targeted therapy is a prevailing method in the treatment of melanoma; however, the accompanying drug resistance is inevitable.SH2 superbinder, a triple-mutant of the Src Homology 2 (SH2) domain, shows potent antitumor ability by replacing natura
Gene therapy for hemophilia has been investigated Chromium for decades but no breakthroughs were made until Nathwani et al.achieved a significant and sustainable factor IX increase in hemophilia B patients in 2011.About eleven years later, in August 2022, the first hemophilia A gene therapy product was approved by the European Commission and hemoph
Introduction Technological advances in bone tissue engineering have improved Chromium orthopaedic implants and surgical techniques for bone reconstruction.This approach allows overcoming inconvenience of the paucity of autologous materials available and donor site morbidity.Aim To demonstrate advances of the past 30 years in the development of bioi
Calcareous foraminifers provide a time-stratigraphic framework to chronicle the development of the Tengiz carbonate platform that thrived from the latest Devonian (late Famennian) into the Middle Pennsylvanian (late Bashkirian).Correlative zones, based on documented foraminiferal assemblages and expressed primarily in terms of Russian horizons, con
Tomato peels are abundant by-products of tomato processing and therefore represent a cost of disposal and an impact on the environment.For this reason, the aim of the present study was to valorise tomato peels to enrich pasta, being these ingredients still rich in antioxidants like carotenoids that are well-known to protect against degenerative dis